Phys.Org (March 21) -- Understanding the sequence-structure-function relationship—the “protein folding problem”—is one of the great, unsolved problems in physical chemistry, and is of inestimable scientific value in exposing the inner workings of life and the rational design of molecular machines. A study by researchers at the University of Illinois at Urbana-Champaign lays the foundations to recover the protein folding landscapes directly from experimental data, providing a route to new understanding and rational design of proteins. Also: ScienceBlog (March 21), R&D Magazine (March 22).